The Fifth Edition of this review book offers medical students a comprehensive examination of the key concepts presented in the first two years of medical school. Since the advent of the USMLE Step 1, which emphasizes an integrated approach to the traditional basic sciences, it is especially important that students work through questions that prepare them for this format. This Fifth Edition will help students review all major content areas covered on the exam, become acquainted with the current exam format, and determine areas where further study may be needed. Key concepts are included at the beginning of each explanation.